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Everything, grouped by its home field. 348 posts in all. Prefer to browse visually? Open the atlas.

Artificial Intelligence

176 posts

"Humans are not great at exceptions, but we are still, at least for now, better than machines"1 min "It's the best time to be alive, when almost everything you thought you knew is wrong"1 min (Lack of) Creative Control1 min 1,000 experiments1 min 1,000 Simultaneous Experiments1 min 3. Behavioral Dynamics1 min 4. Communication Effectiveness1 min 5. Sensitivity to Parameters1 min A different take on the homework machine1 min A small change in the title of a report led by MIT makes a big difference in interpretation2 min A small change in the title of a report led by MIT makes a big difference in interpretation2 min ACH2 min Advantage from AI1 min Agent-based modeling (ABM) and randomized clinical trials (RCTs)1 min Agentic workflows are a pipe dream...2 min Aha moments as percolation transitions1 min AI and illusions of understanding in scientific research1 min AI and Mental Health1 min AI Fatigue: Reflections on the Human Side of AI’s Rapid Advancement1 min AI for fusion1 min AI hashtagagents, evolution is coming for you2 min AI may lower the floor and raise the ceiling, but these are two very different things2 min AI Solves Million-Step Math Problems3 min AI-augmented work moves collectively towards areas richest in data1 min AIgent-Based Modeling1 min Alexis II: Fresh and relevant: Alexis de Tocqueville and Simone Weil1 min An artistic Turing Test from the 160s1 min ANDY CLARK rather than (or together with) JONY IVE1 min Are hashtagLLMs complex (alien) biological systems?1 min Assembly Theory1 min AX is the new UX1 min AX is the new UX, part II1 min Becoming a Super-Scientist2 min Behavioral Drives1 min Bernard Pivot left a lasting impression on me for a somewhat forgotten project2 min Bill Viola1 min Burger Joint Prompt Injection1 min Can AI solve Science?2 min Can you model biology mechanistically?2 min Cassie Kozyrkov1 min Changing Times Twice a Year Is (Probably) Bad for Your Health2 min ChatGPT is not a doctor1 min Chesky disappointment (Aspen)2 min Chollet1 min Click Not2 min Coalesix2 min Cognitive Biases as Sampling Limitations34 min Cognitive One-Way Functions26 min Complexity Science3 min Daron Acemoglu’s paper1 min Deadly Sins1 min DeepSeek2 min Delusions of grandeur and debates about illusions of thinking obscure from the actual, practical usefulness of AI2 min Democracy-as-a-wrapper2 min Discovering state-of-the-art reinforcement learning algorithms1 min Diverging Values1 min DOC Debate1 min Don’t Judge an Article by Its Title4 min Doomprompting is the new doomscrolling1 min Emergent misalignment1 min Enough with AGI, please1 min Evaluation I1 min Evaluation is what matters1 min Evolution is Accelerating5 min Evolution is definitely back, Part II1 min Evolving Surprises2 min Exact Instructions2 min Explosive Preprint about the AI "Leaderboard Illusion"2 min Food Printing1 min Foundation Rwanda2 min Founder Mode1 min Frank Bruni1 min From LLMs to LTMs?1 min Generative exaggeration1 min GitHub Registry1 min H Company1 min Hallucinations part I1 min Hallucinations part II1 min Hallucinations part III1 min hashtagFairness is hard, hashtagAI or not1 min How Might Artificial Intelligence Influence Human Evolution?1 min How to compose LLMs adaptively2 min https://thehardthing.substack.com/p/hundreds-of-daily-decisions1 min Human Nature, Unleashed!3 min Humans are still valuable after all (to other humans, that is)1 min If AI alone > (AI + Human) > Human alone, what is that telling us?3 min It is not about math vs. literature1 min Jack Cowan1 min Jagged AGI is not really AGI1 min Jagged Fascination1 min Jagged Fascination1 min Jagged Thresholds1 min Kahneman1 min Karpathy-level fatigue1 min LegoGPT is here2 min Lie to persuade1 min Lie to persuade1 min LLM Average?1 min Lots of yummy quotables at Human[X] this week, Part III1 min Lots of yummy quotables at Human[X] this week, Part IV1 min Luck and skill 11 min Machines of Loving Grace1 min Managers who can’t understand a solution1 min Managers...1 min Marshmallow evidence1 min Mass Intelligence1 min Mathematical Exploration1 min MCP Night1 min Mikhail Belkin1 min Naïve Ng1 min Novelty and Camouflage2 min Now for a different kind of LLM benchmark!1 min Occam’s razor2 min On Its Head89 min On the "hallucination problem"1 min Paleo-robots and toilet paper1 min Personal Echo Chambers2 min Personal utopia vs. Immanentizing the eschaton3 min Precision1 min Prey Survey Part II1 min Probably not thinking enough about it!1 min Productivity gains from using AI are captured by individuals, not organizations2 min Prompt injections in the physical world1 min Proving a theorem is a one-way function2 min Recall vs Recognition18 min Reeks and Wrecks does not have to be the future3 min Reid Hoffman interview1 min Reward hacking (or "whatever works").1 min Reward hacking, constraint hacking and the infinite complexity of intent2 min Self-Verifying and Mutually Verifying Agents reduce hallucinations and false results1 min Slightly outside of my area of expertise?2 min Software is Dead (not)1 min Sorry but AGI is not a helpful concept3 min Spiritual2 min Spooky, and sometimes brilliant, ideas from AI in science2 min Stack Overflow2 min Stop the "it's just next-token prediction" nonsense2 min Super-long Prompts1 min Teaching LLMs to reason like Bayesians1 min Techbio Foundation Models1 min Ted Chiang and [Terence Tao](https://www.linkedin.com/in/terence-tao-621246/): art, math and AI1 min Terence Tao1 min The "G" in hashtagAGI is sending everyone down a deep and jagged rabbit hole1 min The "win-win" genAI answer engines should strive for1 min The anthropomorphization of AI and the AI-fication of humans1 min The best market days?1 min The Beta-Lactam Band and the Bogus Upsides2 min The Bonabeau enterprise1 min The Fear That Originality Is No Longer Possible1 min The future belongs to curators!2 min The lazy and the curious1 min The logical next step: AI compute for Universal Basic Income1 min The ONE thing I find most exciting about hashtagDeepSeek1 min The Perils of the Imitation Age2 min The weirdness of AI mistakes1 min Thinking Machines... Lab1 min This has nothing to do with AGI2 min Thomas Insel on chatbots1 min Three?1 min Time Spent Eating (cheese)2 min Turing Test for AI Chatbots1 min Use Cases1 min Use cases gone wild with Dunning-Kruger AI1 min Used Meta AI to edit a selfie, now Instagram is using my face on ads targeted at me1 min Vibe reporting at MIT1 min Wall Street still doesn’t understand AI1 min We need a Journal of Disappointing Results1 min What IS Formal Analyses?1 min When I was a rockstar1 min When Not to Use AI as a Cognitive Escalator2 min Who Is the Endosymbiont?2 min Who is using AI to code?1 min Why Programming Was Never About Code1 min Winning at bullshit1 min With Hod1 min You can't tell the difference between AI Slop and great content in your job? Consider another profession.1 min

Human + Machine

4 posts

Augment and Invent2 min Reverse Centaurs2 min Reverse Centaurs, Part II1 min The great value migration2 min

Evolutionary Computing

2 posts

Prey Survey Part I1 min Swarms, gratitude and good karma2 min

Evolution & Life

5 posts

Competence without Comprehension1 min Fitness Beats Truth9 min Pasta Evolution1 min Speciation?1 min The 20/80 Rule of Exploration: Bees, Ants, and Scouts4 min

Open-Endedness

6 posts

Gordon Pask's Evolved Ear and the Grounding Problem6 min Open-Endedness from a Computational Perspective12 min Open-Endedness from a Computational Perspective: A Conceptual Taxonomy9 min Open-Endedness: From Computational Mechanisms to Existential Implications14 min Pask's Electrochemical Pioneers: Self-Organization and Open-Ended Evolution8 min The Future Belongs to Curators4 min

Complexity & Simulation

6 posts

Alexis I1 min Ants and robots1 min Da Vinci, Fukushima, the aerial screw and the neocognitron2 min Da Vinci, Fukushima, the aerial screw and the neocognitron3 min Luck and skill 21 min Olfaction2 min

Innovation & Discovery

10 posts

AHA1 min Cambrian explosion in innovation1 min Dating and Serendipity2 min Proving a theorem is a one-way function2 min Serendipity, penicilin and the prepared mind1 min Serendipity, penicilin and the prepared mind1 min The creativity of mathematical conjectures1 min The prepared mind favors chance1 min Thinking, super slow, about Danny3 min Weak(er) serendipity in Fleming's discovery?1 min

Biology

82 posts

"From geroscience to precision geromedicine: Understanding and managing aging"2 min 1 billion biochemical reactions occur every second in every cell of our bodies1 min 10-2023: Infectious diseases down, non-communicable diseases up2 min 11% of patients with dementia symptoms have a reversible condition. Did you know?2 min 8 interventions in human trials for diseases of aging1 min A More Robust Measure of Gut Imbalance?2 min Adipose Memory1 min Aging research is going mainstream.1 min Aging: genes/diseases/hallmarks1 min An article I thought I would easily dismiss but couldn’t2 min An intriguing answer engine for biology1 min And now we present to you... the volatilome!1 min Antibiotics are not the only culprits2 min Bacterial ubiquitination1 min Beyond FMT1 min Biocomposite Bacillus1 min Biologists, stop putting UMAP plots in your papers3 min Blocking low-grade inflammation will create the new Lipitor(s)2 min Brain Microbiome1 min Cell Vaults2 min Chronic low-grade inflammation2 min Cognitive Dissonance1 min Comment on Tamsin Lewis2 min Control blood pressure, reduce risk of dementia1 min Discovering Intermediates in Biosynthetic Pathways that have Interesting Properties2 min Disentangled latent variables in the hippocampus1 min Distinct neuronal populations in the human brain combine content and context1 min DNA is not destiny1 min DNA Repair within Reach?2 min Engineered bacteria administered intranasally can propel molecules across the brain-blood barrier1 min Eukaryotic phase transition?1 min Exploration gene2 min Extending the years people live without the burden of major age-related diseases should be a national priority1 min FMT ‘Proof of Existence”1 min Food printing1 min Generative 3D printing1 min Genetic engineering of bacteria... inside the gut1 min Global Burden of Disease (2)2 min Health-Associated Core Keystone (HACK)1 min Healthspan, a macro-view2 min Heritability of intrinsic human life span is about 50% when confounding factors are addressed1 min How to Build the Virtual Cell with Artificial Intelligence1 min I knew it!1 min IL-11 and aging1 min Inflammatory lack of pleasure ...2 min It's like saying that everything in the Mona Lisa depends on the paint.2 min Measurable benefits of treating low-grade inflammation2 min Mind-blowing discovery if confirmed: viruses hiding inside gut bacteria as phages3 min New T2D peptide1 min Nonuniversality of inflammaging across human populations[?]2 min Not a U-Shape1 min Nothing is ever simple with the microbiome2 min Obesity-related inflammation or inflammation-related obesity?1 min Of mice and men: "Matthew effect" and lucky breaks2 min Personalized Medicine, Unevenly Distributed3 min Placebo Circuit1 min Predicting Disease Trajectories1 min Protein Data Bank1 min Protein monitoring and chronic inflammation2 min Reading Derek Lowe with Perplexity2 min Silver Linings1 min SleepFM1 min Social networks and microbiome sharing2 min Take metformin OR exercise, but don't do both4 min The cell is not a soup1 min The Epstein-Barr virus1 min The geometric shapes of life on Earth occupy a tiny fraction of the possible1 min The gut microbiome is always more complex than you think2 min The human gut microbiota can synthesize bioactive serotonin!2 min The rise of healthspan as the dominant longevity concept (as it should)1 min Tim Opler on the history of aging1 min Tim Opler’s Women’s Health history1 min Ultra-Processed Obesity7 min Vaults1 min Virtual interactions, real immune response1 min VO2 max and Inflammation2 min We have a lot of agency when it comes to increasing our healthspan2 min Weak Correlation Between DNA Methylation Clocks and Frailty2 min What is Life?1 min Who will pay for an anti-aging drug?1 min Why Greenland?1 min Winner-take-all molecular network1 min

Biotech & Pharma

43 posts

Activation, inhibition, same effect: the infinite complexity of human biology2 min AI in the biotech/pharma R&D productivity equation2 min Algorithmic Control of Care2 min Approved Drugs1 min Are Chinese biotech cycle times really crazy?1 min BioAge Meeting1 min BioTechBio1 min Can protein expression be ‘solved’?4 min Change in P(ts) per US$2 min Chemical space(s), a concept still evolving2 min Chemical space(s), a concept still evolving, part II2 min China 11 min Controlled colonization of the human gut with a genetically engineered microbial medicine2 min Could Life Insurance become the new Health Insurance?1 min E coli delivering serotonin1 min Elliot Hershberg unpacked2 min Fantastic Four1 min Fractal enzyme(s)1 min Full-Stack AI companies2 min GLP-1 payback time2 min Holistic Drug Development (HDD) = Holistic Decision Making2 min Is $112m really that cheap for a preclinical GLP-1 RA?1 min Is it time to retire druglikeness?2 min Is Texas cheaper than China?1 min Lack of standards is still impeding preclinical deals1 min Lots of yummy quotables at Human[X] this week, Part I1 min Lots of yummy quotables at Human[X] this week, Part II1 min Merck on a Chinese roll!1 min Pharma & Biotech has the "Magnificent One"1 min Pharmacomicrobiomics1 min Phenomenal Decoding Bio article by Zahra Khwaja and Matthew Nemeth about Benjamine Liu and Linhao Zhang's "AI-native biopharma" company, Formation Bio.1 min The Chorus Revolution: How Eli Lilly's Virtual R&D Unit Redefined Pharmaceutical Productivity11 min The cost of making Orforglipron2 min The Long Cycle of Pharma R&D1 min The Magnificent One!1 min The Phase II wall is the next monumental challenge for AI1 min There is something missing in the conversation about AI drugs1 min This compound looks too much like a detergent2 min Value Inflection Points1 min What Matters to Pharma and Biotech R&D Success?1 min Will all our drugs come from China?2 min Wing@JPM1 min Zbiotics1 min

Cognitive Science

4 posts

As long as customers are human (agents anyone?)2 min Bias≠Discrimination2 min Inversions of Wisdom3 min Unskilled and unaware of it1 min

Senses & Perception

9 posts

Alexis III2 min Core ideas that have persisted2 min Don’t Judge an Article by Its Title2 min Fruit flies are people too1 min Gradual change blindness1 min The Expanded Human Senses18 min The Perfect Egg2 min The verification bottleneck2 min Why do we have to watch podcasts?1 min

Science & Method

1 posts

Types of Scientific Discovery1 min