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Artificial Intelligence

228 posts

"But, in truth, the David who solved the K⁡(π,1) conjecture1 min "Humans are not great at exceptions, but we are still, at least for now, better than machines"1 min "It's the best time to be alive, when almost everything you thought you knew is wrong"1 min "The AI intends to run the nuclear power plant, but gets distracted reading French poetry, and there is a meltdown"1 min (Lack of) Creative Control1 min 1,000 experiments1 min 1,000 Simultaneous Experiments1 min 3 days ago Mike Krieger resigned from Figma's board "the same day1 min 80 x $9bn = $720bn1 min @scott belsky3 min A different take on the homework machine1 min A short article by WIRED's Will Knight may be one2 min A small change in the title of a report led by MIT makes a big difference in interpretation2 min A small change in the title of a report led by MIT makes a big difference in interpretation2 min About 15 years ago, with the Icosystem team, I wanted to apply2 min Advantage from AI1 min Agent-based modeling (ABM) and randomized clinical trials (RCTs)1 min Agentic workflows are a pipe dream...2 min Aha moments as percolation transitions1 min AI agents, evolution is coming for you2 min AI and illusions of understanding in scientific research1 min AI and Mental Health1 min AI Assistance Reduces Persistence and Hurts Independent Performance2 min AI Fatigue: Reflections on the Human Side of AI’s Rapid Advancement1 min AI for fusion1 min AI Solves Million-Step Math Problems3 min AI-augmented work moves collectively towards areas richest in data1 min AIgent-Based Modeling3 min Alexis II: Fresh and relevant: Alexis de Tocqueville and Simone Weil1 min An artistic Turing Test from the 1960s1 min ANDY CLARK rather than (or together with) JONY IVE1 min Anna Marie Wagner and Christina Agapakis thank you for this!1 min Aparna Chennapragada, Cassie Kozyrkov, Thomas Wolf, Kerem Tomak, Stefan Weitz, Charlene Li,2 min Are LLMs complex (alien) biological systems?1 min As long as customers are human (agents anyone?)2 min Assembly Theory1 min Atlan's Prukalpa1 min AX is the new UX2 min AX is the new UX, part II1 min Back to the 2026 Stanford Institute for Human-Centered Artificial Intelligence (HAI) AI1 min Becoming a Super-Scientist2 min Behavioral Drives1 min Bernard Pivot left a lasting impression on me for a somewhat forgotten project1 min Bidirectional Subliminal Learning2 min Bill Viola1 min Burger Joint Prompt Injection1 min Can AI solve Science?2 min Can you model biology mechanistically?2 min Cassie Kozyrkov1 min Chance sometimes favors the unprepared mind too2 min Changing Times Twice a Year Is (Probably) Bad for Your Health2 min Charts from a16z always attract attention.2 min ChatGPT is not a doctor1 min Chesky disappointment (Aspen)2 min Chollet1 min Claude Shannon's wife Betty was a computer1 min Click Not2 min Coalesix2 min Cognitive Biases as Sampling Limitations34 min College student "exercising" their critical thinking muscle with AI1 min Complexity Science3 min Concise depiction of the strategic differences between OpenAI and Anthropic by Robinhood's1 min Conor Grennan1 min Daron Acemoglu’s paper1 min Deadly Sins1 min DeepSeek2 min Delusions of grandeur and debates about illusions of thinking obscure from the actual, practical usefulness of AI2 min Democracy as a wrapper2 min Discovering state-of-the-art reinforcement learning algorithms1 min Disruption and earnings calls eat CAP for breakfast2 min Diverging Values1 min DOC Debate1 min Doomprompting is the new doomscrolling1 min Emergent misalignment1 min Evaluation I1 min Evaluation is what matters1 min Evolution is Accelerating4 min Evolution is definitely back, Part II1 min Evolving Surprises2 min Exact Instructions2 min Explosive Preprint about the AI "Leaderboard Illusion"6 min Fairness is hard, AI or not1 min Food Printing1 min Foundation Rwanda2 min Founder Mode1 min Frank Bruni1 min From LLMs to LTMs?1 min Generative exaggeration1 min GitHub Registry1 min Google's new search experience = prompt injection galore1 min H Company1 min Hallucinations part I3 min High variance kills traditional SaaS unit economics2 min How Might Artificial Intelligence Influence Human Evolution?1 min How to compose LLMs adaptively2 min Huge consequences from a simple observation1 min Human Nature, Unleashed!1 min Humans are still valuable after all (to other humans, that is)1 min I am not sure many people realize how Hugging Face is quietly1 min I finally got to meet Hugging Face/Pollen Robotics' Reachy Mini "in person.1 min I have recently seen an upsurge of interest in...1 min I made my own leaderboard picture from the Arena agent leaderboard.1 min I saw a typo today about Pasteur's famous quote.1 min It is not about math vs. literature1 min It's fantastic, but let's be honest, no one is interested1 min Jack Cowan1 min Jagged Fascination1 min Jagged Fascination1 min Jagged Thresholds1 min Kahneman1 min Karpathy-level fatigue1 min Last week I wrote about buying raicursive.com (I did acquire1 min LegoGPT is here2 min Lie to persuade1 min Lie to persuade1 min LLM "hallucinations" persist largely because of how we evaluate models, not just1 min LLM Average?1 min LLMs see patterns everywhere as they try to match human input to something they have trained on.1 min Lots of yummy quotables at Human[X] this week, Part III1 min Lots of yummy quotables at Human[X] this week, Part IV1 min Luck and skill 11 min Machines of Loving Grace1 min Managers who can’t understand a solution1 min Managers...1 min Marshmallow evidence1 min Mass Intelligence1 min Mathematical Exploration1 min MCP Night1 min Mikhail Belkin1 min Naïve Ng1 min Nice explainer: https://ibmm-unibe-ch.github.io/SMILES_or_SELFIES/1 min Not having an opinion on SpaceX is going to cost you. How much must you pay not to play1 min Not ONE but TWO AI (Co-)Scientist articles popped up in Nature today2 min Not sure what to add.1 min Novelty and Camouflage2 min Now for a different kind of LLM benchmark!2 min Now I question everything David Epstein says2 min Now you know why you h̶a̶t̶e̶ are frustrated with Opus 4.7.1 min Occam’s razor2 min Oh Jevons where art thou, really2 min On Its Head89 min OpenClaw...1 min Outplaying elite table tennis players with an autonomous robot1 min Paleo-robots and toilet paper1 min Pax latrina1 min Perf-per-Watt2 min Personal Echo Chambers2 min Personal SaaS ≠ Enterprise SaaS2 min Personal utopia vs. Immanentizing the eschaton1 min Precision1 min Prey Survey Part II1 min Probably not thinking enough about it!1 min Prompt injections in the physical world1 min Proving a theorem is a one-way function2 min Raffi Krikorian this is great!2 min Reid Hoffman interview1 min Reward hacking (or "whatever works").1 min Reward hacking, constraint hacking and the infinite complexity of intent2 min Righteousness is in the eye of the beholder1 min Self-Verifying and Mutually Verifying Agents reduce hallucinations and false results1 min Slightly outside of my area of expertise?2 min Software is Dead (not)1 min Sometimes, exercise is the point1 min Sorry but AGI is not a helpful concept2 min Spooky, and sometimes brilliant, ideas from AI in science2 min Stack Overflow2 min Stop the "it's just next-token prediction" nonsense2 min Study Shows AI Can Pass The Turing Test More Reliably Than Humans1 min Super-long Prompts1 min Teaching LLMs to reason like Bayesians1 min Techbio Foundation Models1 min Ted Chiang and Terence Tao: art, math and AI1 min Terence Tao1 min Thanks to an amazing (please read below) paper in Scientific Reports we2 min The "G" in AGI is sending everyone down a deep and jagged rabbit hole1 min The "win-win" genAI answer engines should strive for1 min The anthropomorphization of AI and the AI-fication of humans1 min The best market days?1 min The Bonabeau enterprise1 min The f***g loop has to change3 min The future belongs to curators!2 min The lazy and the curious1 min The logical next step: AI compute for Universal Basic Income1 min The logical next step: AI compute for Universal Basic Income1 min The most concise description by Victor Coimbra of a Jevons-like inflation1 min The ONE thing I find most exciting about DeepSeek1 min The Perils of the Imitation Age2 min The power of verification2 min The weirdness of AI mistakes1 min Think AI is a productivity game-changer for your business?2 min Thinking Machines... Lab1 min Thinking, super slow, about Danny2 min This has nothing to do with AGI2 min This is an "old" post by John List (4 months in AI3 min This young man is about to make a terrible decision.2 min Thomas Insel on chatbots1 min Time Spent Eating (cheese)2 min Timing matters in the Cursor acquisition3 min Turing Test for AI Chatbots1 min Two posts on the same preprint (the preprint is behind a paywall1 min Unknowable Intelligence1 min Untitled1 min Usage per user is growing much faster than overall user growth1 min Use Cases1 min Use cases gone wild with Dunning-Kruger AI1 min Vemödalen The Fear That Originality Is No Longer Possible Day 21 min Vibe reporting at MIT1 min Wall Street still doesn’t understand AI1 min We need a Journal of Disappointing Results1 min What are the most influential papers on agent-based modeling (ABM)?1 min What IS Formal Analyses?1 min When I was a rockstar1 min Who Is the Endosymbiont?1 min Who is using AI to code?1 min Why are humans still in the loop with advancing AI capabilities1 min Why Do "Nigerian" Scammers Say They are From Nigeria1 min Why Programming Was Never About Code1 min Will AI become a powerful source of power to its host, or will the host evolve into a meat-based embodiment for AI?1 min Winners and Losers in the Upcoming Mega IPOs (SpaceX, OpenAI, Anthropic) spacexipo.bonabeauapps.com1 min Winning at bullshit1 min With genAI, anyone can be an artist (in a very personal and not always shareable way).1 min With Hod1 min With the upcoming megacap/thin-float IPOs of SpaceX, OpenAI and Anthropic, the impact1 min Y Combinator2 min You can't tell the difference between AI Slop and great content in your job? Consider another profession.1 min You in Control?1 min You want to simulate the impact of the thin-float, fast-entry, upcoming mega IPOs?1 min You will find a number of really interesting graphs in the Stanford1 min

Human + Machine

6 posts

Augment and Invent2 min Reeks and Wrecks does not have to be the future2 min Reverse Centaurs2 min Reverse Centaurs, Part II1 min The great value migration2 min When Not to Use AI as a Cognitive Escalator2 min

Evolutionary Computing

2 posts

Prey Survey Part I1 min Swarms, gratitude and good karma2 min

Evolution & Life

8 posts

A warplane theory of poop1 min Competence without Comprehension1 min Fitness Beats Truth9 min Human foragers are not that different from other animals. Or from slot machine addicts.1 min Long term evolution of antibiotic resistance in a bacterial community2 min Pasta Evolution1 min Speciation?1 min The 20/80 Rule of Exploration: Bees, Ants, and Scouts4 min

Open-Endedness

6 posts

Gordon Pask's Evolved Ear and the Grounding Problem6 min Open-Endedness from a Computational Perspective10 min Open-Endedness from a Computational Perspective: A Conceptual Taxonomy9 min Open-Endedness: From Computational Mechanisms to Existential Implications14 min Pask's Electrochemical Pioneers: Self-Organization and Open-Ended Evolution8 min The Future Belongs to Curators4 min

Complexity & Simulation

8 posts

Alexis I1 min Ants and robots1 min Conscious Simulation1 min Da Vinci, Fukushima, the aerial screw and the neocognitron2 min Da Vinci, Fukushima, the aerial screw and the neocognitron3 min Healthy life expectancy AT BIRTH is strongly negatively correlated with how much is spent on the last years of life1 min Luck and skill 21 min Olfaction2 min

Innovation & Discovery

9 posts

AHA1 min Cambrian explosion in innovation1 min Dating and Serendipity2 min Proving a theorem is a one-way function2 min Serendipity, penicilin and the prepared mind1 min Serendipity, penicilin and the prepared mind1 min The creativity of mathematical conjectures1 min The prepared mind favors chance1 min Weak(er) serendipity in Fleming's discovery?1 min

Biology

108 posts

"From geroscience to precision geromedicine: Understanding and managing aging"2 min 1 billion biochemical reactions occur every second in every cell of our bodies1 min 11% of patients with dementia symptoms have a reversible condition. Did you know?2 min 1990-2023: Infectious diseases down, non-communicable diseases up2 min 8 interventions in human trials for diseases of aging1 min A More Robust Measure of Gut Imbalance?2 min A whole new level of gut-brain connection1 min Adipose Memory1 min Aging research is going mainstream.1 min Aging: genes/diseases/hallmarks1 min An article I thought I would easily dismiss but couldn’t2 min An intriguing answer engine for biology1 min And now we present to you... the volatilome!1 min Ansel Adams, a generative HI (human intelligence)1 min Antibiotics are not the only culprits2 min Bacterial ubiquitination1 min Beyond FMT1 min Biocomposite Bacillus1 min Biologists, stop putting UMAP plots in your papers3 min Blocking low-grade inflammation will create the new Lipitor(s)2 min Brain Microbiome1 min Breaking news in the world of methane burps1 min Can protein expression be ‘solved’?1 min Cell Vaults2 min Chronic low-grade inflammation2 min Cognitive Dissonance1 min Comment on Tamsin Lewis2 min Discovering Intermediates in Biosynthetic Pathways that have Interesting Properties2 min Disentangled latent variables in the hippocampus1 min Distinct neuronal populations in the human brain combine content and context1 min DNA is not destiny1 min DNA Repair within Reach?2 min Engineered bacteria administered intranasally can propel molecules across the brain-blood barrier1 min Eric Topol, MD1 min Eukaryotic phase transition?1 min Exploration gene1 min Extending the years people live without the burden of major age-related diseases should be a national priority1 min FMT ‘Proof of Existence”1 min Food printing1 min For those who were excited to see a zebra's butt on my1 min Full-body scan in 60 seconds with sound and water: no radiation, no magnetic field2 min Generative 3D printing1 min Genetic engineering of bacteria... inside the gut1 min Global Burden of Disease (2)2 min Gut microbiome composition does not matter...2 min Health-Associated Core Keystone (HACK)1 min Healthspan, a macro-view2 min Heritability of intrinsic human life span is about 50% when confounding factors are addressed1 min How to Build the Virtual Cell with Artificial Intelligence1 min I knew it!1 min I was wrong (it seems3 min IL-11 and aging1 min Imidazole propionate is a driver and therapeutic target in atherosclerosis2 min In the eight years leading up to a dementia diagnosis, the median U.S.1 min Inflammatory lack of pleasure ...2 min It's like saying that everything in the Mona Lisa depends on the paint.3 min Longevity Fantasy Football, not March Madness1 min Longevity Priority Matrix1 min Measurable benefits of treating low-grade inflammation2 min Microbiota-driven antitumour immunity mediated by dendritic cell migration1 min Mind-blowing discovery if confirmed: viruses hiding inside gut bacteria as phages2 min My friend Daniel Levitin wrote "This Is Your Brain on Music." My1 min New T2D peptide1 min Nonuniversality of inflammaging across human populations[?]2 min Not a U-Shape1 min Nothing is ever simple with the microbiome2 min Now I know why everyone around me is aging faster and seems inflamed. And multimorbid1 min Obesity-related inflammation or inflammation-related obesity?1 min Of mice and men: "Matthew effect" and lucky breaks2 min Personalized Medicine, Unevenly Distributed2 min Placebo Circuit1 min Predicting Disease Trajectories1 min Promising research from a Google Research and University of Cambridge's Institute1 min Protein Data Bank1 min Protein monitoring and chronic inflammation2 min Reading Derek Lowe with Perplexity2 min Relax!1 min Remarkable preprint by a team that includes Caterina Gasperini and Lee Rubin1 min Silver Linings1 min SleepFM1 min So tired of correlations being SOLD as causal in longevity "science".1 min Social networks and microbiome sharing2 min Spiritual2 min Take metformin OR exercise, but don't do both2 min The cell is not a soup1 min The effect of one course of antibiotics on the gut microbiome may persist for several years2 min The Epstein-Barr virus1 min The geometric shapes of life on Earth occupy a tiny fraction of the possible1 min The gut microbiome is always more complex than you think2 min The human gut microbiota can synthesize bioactive serotonin!2 min The rise of healthspan as the dominant longevity concept (as it should)1 min The second volume of Tim Opler's Women's Health history is finally out!2 min The super short and catchy title1 min There is a lot to unpack in this rich and sophisticated2 min This is mind-blowing work by Nikolai Slavov, Shira Tsour and team.2 min Tim Opler on the history of aging1 min Tim Opler’s Women’s Health history1 min Ultra-Processed Obesity2 min Untitled1 min Vaults1 min Virtual interactions, real immune response1 min VO2 max and Inflammation2 min We have a lot of agency when it comes to increasing our healthspan2 min Weak Correlation Between DNA Methylation Clocks and Frailty2 min What is Life?1 min Why Greenland?1 min Winner-take-all molecular network1 min Your immune system doesn't just wear out with age, it actively reprograms itself2 min

Biotech & Pharma

51 posts

A badly needed article (https://lnkd.in/gr_MSi9W) reminds us that of ONE1 min A creative tour de force in molecular design in this article "GLP-1R–GIPR–PPARα/γ/δ1 min A recent blog post by the always insightful Elliot Hershberg caught my2 min Activation, inhibition, same effect: the infinite complexity of human biology2 min AI in the biotech/pharma R&D productivity equation2 min Algorithmic Control of Care2 min Approved Drugs1 min Are Chinese biotech cycle times really crazy?1 min BioAge Meeting1 min BioTechBio1 min Change in P(ts) per US$2 min Chemical space(s), a concept still evolving2 min Chemical space(s), a concept still evolving, part II2 min China 11 min China 21 min Controlled colonization of the human gut with a genetically engineered microbial medicine2 min E coli delivering serotonin1 min Elliot Hershberg unpacked2 min Fantastic Four1 min Fractal enzyme(s)1 min Full-Stack AI companies2 min GLP-1 payback time2 min Holistic Drug Development (HDD) = Holistic Decision Making2 min Is $112m really that cheap for a preclinical GLP-1 RA?1 min Is it time to retire druglikeness?1 min Is Texas cheaper than China?1 min Lack of standards is still impeding preclinical deals1 min Lots of yummy quotables at Human[X] this week, Part I1 min Lots of yummy quotables at Human[X] this week, Part II1 min Merck on a Chinese roll!1 min ould Life Insurance become the new Health Insurance?1 min Pharmacomicrobiomics1 min Phenomenal Decoding Bio article by Zahra Khwaja and Matthew Nemeth about Benjamine Liu and Linhao Zhang's "AI-native biopharma" company, Formation Bio.1 min Reimagining human-centric drug development with new approach methodologies2 min Tech has the the "Magnificent Seven"1 min The Chorus Revolution: How Eli Lilly's Virtual R&D Unit Redefined Pharmaceutical Productivity11 min The cost of making Orforglipron2 min The Long Cycle of Pharma R&D1 min The Magnificent One!1 min The Phase II wall is the next monumental challenge for AI1 min There is something missing in the conversation about AI drugs1 min This compound looks too much like a detergent2 min This is a cool graph from a timely Reuters article drawing1 min This is a cool graph from a timely Reuters article drawing1 min Value Inflection Points1 min Very exciting paper in Science Magazine this week by a Harvard University2 min What Matters to Pharma and Biotech R&D Success?1 min Who will pay for an anti-aging drug?1 min Will all our drugs come from China?2 min Wing@JPM1 min Zbiotics1 min

Cognitive Science

5 posts

Bias≠Discrimination2 min Cognitive One-Way Functions7 min Inversions of Wisdom3 min Recall vs Recognition6 min Unskilled and unaware of it1 min

Senses & Perception

10 posts

Alexis III1 min Core ideas that have persisted2 min Don’t Judge an Article by Its Title2 min Don’t Judge an Article by Its Title2 min Fruit flies are people too1 min Gradual change blindness1 min The Expanded Human Senses7 min The Perfect Egg2 min The verification bottleneck1 min Why do we have to watch podcasts?1 min

Science & Method

1 posts

Types of Scientific Discovery1 min