Fantastic Four
In an interview for the fantastic Longevity.Technology, Nir Barzilai lists the 4 highest-scoring FDA-approved drugs for humans. It is striking that 3 of the 4 drugs were primarily developed as anti-diabetic products.
"We measure gerotherapeutics on a scale out of 12 – the one that gets 12 points is SGLT2 inhibitors, an anti-diabetic drug which is prescribed much more for non-diabetic patients, for both preventive of deterioration in kidney disease and cardiovascular disease. The other drugs are metformin on 11 points, biphosphonates for osteoporosis, 11 points, and 10 points is GLP-1 inhibitors. These are four, FDA-approved drugs. FDA-approved drugs have safety, they have efficacy, they have years of use."