I knew it!

Around age 45, I felt like my body was suddenly becoming more fragile. 😱

According to an article in Nature Aging on August 14th, 2024 by the prolific Michael Snyder and his team at Stanford University (Nonlinear dynamics of multi-omics profiles during human aging, Open Access!: link), two major shifts in our internal make up take place over the lifetime: molecules and microbiomes exhibit dramatic changes in nature and numbers in the mid-40s and early 60s, independent of gender.

"In people in their 40s, significant changes were seen in the number of molecules related to alcohol, caffeine and lipid metabolism; cardiovascular disease; and skin and muscle. In those in their 60s, changes were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle." (link).

Given my experience with my mid-40s, I am not looking forward to my early 60s. Or it might be a good time to adjust lifestyle.