Tim Opler on the history of aging

❤️ Amazing resource put together by Stifel Bank Tim Opler on the history of aging. The deck here is truncated by a dozen pages as it is more than the max 300 pages allowed on LinkedIn!

⚡ While I don't necessarily agree with some of the choices (the "key" papers list can be debated ad nauseam) or descriptions (for example, why dismiss Élie Metchnikoff, the "father of innate immunity" and microbiome groupie so summarily?), I find this compendium to be thoroughly researched and providing some needed historical depth.

💡 Although the deck does not dwell on the philosophical implications of longevity vs healthspan, it does point out the first article to use the expression "healthspan" for healthy lifespan, John Rowe and Robert Kahn's 1987 Science Magazine article "Human Aging: Usual and Successful" (Science 237, 143-149) and other influential healthspan articles, "Geroscience: linking aging to chronic disease" (Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA., Richardson A., Schadt E. E., Wyss-Coray T. and Sierra F. Cell, Nov 6, 2014; 159(4):709-13), and the more recent "Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework" (Wang B, Szücs A, Sandalova E, Horberg EJ, O'Keefe PA, Island L, Meij HJ, Rosenthal S, Maier AB., Geroscience. 2025 Feb 24).

cc: Alex Colville, Richard Barker, Brent Hoberman, Carolyn Dawson, David A. Sinclair A.O., Ph.D., Kyle O'Brien, Hevolution Foundation, David Barzilai MD PhD MBA MS DipABLM, Daniel Promislow, Jane Metcalfe, Louis Hawthorne, Sergey Jakimov, Salah Mahmoudi, Priyanka Joshi, Dirk Probstel, Pedro "Henrich" Azevedo, Johannes Mallinckrodt, Eric Verdin, Kristen Fortney, Alex Zhavoronkov, "Joe Betts-LaCroix"